Throughout history, herbalists have long held the belief that whole plants are more potent than their individual elements, recognizing a concept called synergy. When a compound is synergistic, that means the active elements create a combined impact greater than the impact of each element on its own. It’s kind of like saying 1+1=3.

While synergy explains the concept of the combined effect of active compounds, the entourage effect explains the effects of combining inactive elements.

Israeli researcher Raphael Mechoulam and his team recognized that cannabis contains many inactive (inert) compounds that appeared to have no individual effects. When these inert elements combine, they create active elements. Once activated, these once inert elements intensify the synergistic properties of the plant and strengthen the potential results.

This reaction is now known as the entourage effect. The entourage effect, first published in 1998,  explains how each of the potentially beneficial elements in hemp oil is multiplied and magnified by the effects of the others.

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